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Research Therapeutic

🇮🇷 Iranian ELF-EMF Study Shows HER-2 Breast Cancer Cells Most Vulnerable to Field-Induced Apoptosis

July 18, 2026 (EMFS)
Jul 17, 2026 (original)
Source: Breast J
Source category: Therapeutic
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An Iranian in vitro study exposed three breast cancer molecular subtypes to ELF-EMF (1 Hz, 100 mT, 2 h/day, 5 days) and found HER-2-enriched SKBR-3 cells showed ~78% apoptosis induction versus 22% or 11% in the other lines. Triple-negative and luminal-A subtypes resisted the effect by upregulating antioxidant genes such as SOD1.
🔬 This research is covered in EMF Signal's section on therapeutic EMF applications. It investigates controlled use of electromagnetic fields as potential treatment, not environmental exposure.

"the mRNA expression level of SOD1 and SOD2 increased significantly in the MDA-MB-231, in addition to these two genes, the expression level of SOD3 and GSR increased in the MCF-7 cells but not in the SKBR-3."

— Shayeghan et al.

"our results confirmed that ELF-EMF induced ROS-dependent apoptosis, especially in HER-2-enriched breast cancer cells (the SKBR-3), in a p53-independent manner."

— Shayeghan et al.

"Other molecular subtypes (MDA-MB-231 as TNBC, or MCF-7 as luminal A) showed resistance against the ROS level increasing and subsequent apoptosis induction by using antioxidant genes, especially SOD1."

— Shayeghan et al.

Source

Pivotal Factors in Breast Cancer Molecular Subtypes Apoptosis Induction by ELF-EMF; Ki-67, ROS Level, HER-2, and SODs. pubmed.ncbi.nlm.nih.gov

📄 Underlying Research

Pivotal Factors in Breast Cancer Molecular Subtypes Apoptosis Induction by ELF-EMF; Ki-67, ROS Level, HER-2, and SODs.

Shayeghan et al. (2026) The Breast Journal Journal Level 1ⓘ

🔗 DOI 📚 PubMed

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