50 Hz ELF-EMF Altered Lipids and Development in C. elegans Mutant

A 2026 study in Ecotoxicology and Environmental Safety exposed ire-1 mutant Caenorhabditis elegans worms to 50 Hz extremely low-frequency electromagnetic fields. The authors report altered lipid metabolism, calcium dysregulation, ER-stress markers, oxidative-stress responses, and developmental inhibition, including reduced body length and brood size.

"This study assessed the effects and underlying mechanisms of 50 Hz extremely low-frequency electromagnetic field (ELF-EMF) on lipid metabolism and development in ire-1 mutant Caenorhabditis elegans."

— Yongyan Sun et al.

"Lipidomic profiling revealed 87 lipids with significant alterations following ELF-EMF exposure, and Biological Pathway Analysis (BioPAN) revealed activated conversion of phosphatidylserine to phosphatidylethanolamine, enhanced dihydroceramide synthesis, and suppressed lysophosphatidylinositol to phosphatidylinositol in ire-1 worms."

— Yongyan Sun et al.

"Developmental inhibition was observed, characterized by 22.3% reduction in body length and 28.7% decrease in brood size."

— Yongyan Sun et al.

"In summary, 50 Hz ELF-EMF exposure can disrupt both lipid metabolism and developmental processes in ire-1 worms, inducing striking calcium homeostasis dysregulation, ER stress, and oxidative stress responses."

— Yongyan Sun et al.

📄 Underlying Research

Effects and mechanisms of lipidomic and development alterations in ire-1 mutant Caenorhabditis elegans under extremely low-frequency electromagnetic field exposure

Yongyan Sun et al. (2026) Ecotoxicology and Environmental Safety Journal Level 2ⓘ

🔗 DOI 📚 PubMed

🧬 50 Hz ELF-EMF Altered Lipids and Development in C. elegans Mutant

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📄 Underlying Research